O-PCE HCL Powder Product Info

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What is O-PCE?

2′-Oxo-PCE (also referred to as Eticyclidone or O-PCE) is a relatively obscure novel dissociative compound belonging to the arylcyclohexylamine class. When administered, it induces a range of effects including dissociation, anesthesia, stimulation, and hallucinations. Its chemical structure is closely related to other arylcyclohexylamines such as MXE, 3-MeO-PCE, and deschloroketamine, and it is believed to exert its effects primarily through NMDA receptor antagonism.

The structural similarities between O-PCE and compounds like DCK and ketamine, which have been suggested to possess antibacterial properties, raise questions about whether O-PCE might share these characteristics. However, due to the limited scientific research available, the validity of this speculation remains uncertain. Users should be aware that prolonged use of this substance could potentially pose significant risks to health and the immune system, should these properties be confirmed.

O-PCE exemplifies a modern designer drug, intentionally designed to replicate or substitute the functional and structural attributes of its predecessors. It has recently gained popularity among online research chemical vendors, where it is marketed as a designer drug alternative to MXE and other dissociatives for recreational use. In contrast to many other research chemical dissociatives, there is a notable scarcity of scientific literature regarding O-PCE, particularly concerning its toxicity, potential for addiction, and abuse in humans.

Given its novelty and the very brief history of human consumption, all information pertaining to this compound should be approached with extreme caution. Users are advised to refrain from frequent redosing, as it is reported to be relatively easy to overdose due to its potency and stimulating effects. It is highly recommended to employ harm reduction strategies if one chooses to use this substance.

Chemical Properties

O-PCE, also known as 2′-Oxo-PCE, is classified within the arylcyclohexylamine chemical group. These drugs are characterized by their unique structures, which feature a cyclohexane ring attached to an aromatic ring, along with an amine group. For instance, deschloroketamine consists of a phenyl ring connected to a cyclohexane ring that is substituted with an oxo group (cyclohexanone) at the R1 position. An amino ethyl chain (-NCH2CH3) is bound to the adjacent alpha carbon (R2) of the cyclohexanone ring. In contrast to DCK and ketamine, which contain an amino methyl chain, 2′-Oxo-PCE, like MXE, features an amino ethyl chain. The primary distinction between 2′-Oxo-PCE and DCK lies in the length of their respective carbon chains.

Pharmacological Effects

Due to the limited research available on O-PCE, discussions regarding its pharmacology are largely speculative, based on its chemical structure and subjective effects that resemble those of other arylcyclohexylamine dissociatives, such as ketamine, PCE, and methoxetamine (3-MeO-2′-Oxo-PCE). Although no scientific studies have been conducted to confirm these assertions, structure-activity relationship analyses indicate that 2′-Oxo-PCE likely exerts its effects primarily as an NMDA receptor antagonist, with the potential involvement of other neurotransmitter systems.

NMDA receptors are a subtype of receptors for glutamate, the principal excitatory neurotransmitter in the nervous system. These receptors facilitate the passage of electrical signals between nerve cells in the brain and spinal cord; for this signaling to occur, the receptor must be activated. NMDA receptor antagonists disrupt this signaling process by blocking the receptors, leading to a disconnection in information flow within the nervous system. This disruption can result in loss of sensation (anesthesia), impaired motor coordination, and ultimately, the experience commonly referred to as the “K-hole.”

Technical Info

Product Name: O-PCE hydrochloride
Other Name(s): 2′-oxo-PCE, eticyclidone hydrochloride
IUPAC Name: 2-(ethylamino)-2-phenyl-cyclohexanone hydrochloride
CAS: 4551-92-2
Molar Mass: 253.8 g/mol

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How to Buy O-PCE HCL Powder online

You can buy O-PCE HCL Powder and other research chemicals here at Chemical Collective. All of our chemicals are third party lab tested. If you wish to see HNMR results for O-PCE HCL Powder or any other chemical, just email us at

Responsible Research with O-PCE HCL Powder

Always practice responsible research. You should read and educate yourself before undertaking research with any chemical. Never conduct research with a chemical without learning about it first.

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O-PCE HCL Powder is sale for research purposes only and not for human consumption!

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O-PCE HCL Powder last stock update: January 2025