5-MeO-DMT Freebase Product Info

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Important Note on 5-MeO-DMT and DMT

It is crucial to understand that while 5-MeO-DMT and DMT share chemical similarities, they possess distinct effects and safety profiles. Therefore, 5-MeO-DMT should not be substituted for DMT; they must be regarded as entirely different substances and treated accordingly.

What is 5-MeO-DMT?

5-MeO-DMT, often referred to as “The God Molecule,” is a psychedelic compound within the tryptamine class. It occurs naturally in a variety of plant species and in at least one toad species, the Sonoran Desert toad. For more information, we recommend Hamilton Morris’s pamphlet “Bufo Alvarius: The Psychedelic Toad of the Sonoran Desert.”

This compound is closely related to DMT and 5-HO-DMT and has been traditionally utilized as an entheogen in South American tribal ceremonies.

In recent years, 5-MeO-DMT has gained significant popularity, with many anecdotal reports highlighting its potential as a healing agent. Mainstream media outlets, including Forbes, have also explored the healing possibilities of this substance.

Although research on 5-MeO-DMT is still limited, some studies have corroborated these anecdotal claims. In a recent preliminary study, 42 participants who consumed 5-MeO-DMT reported reductions in depression and anxiety, along with increased life satisfaction and mindfulness. These effects were observed to persist for at least four weeks following the initial assessment.

Another study involving 362 individuals who had used 5-MeO-DMT found that 80% of respondents reported improvements in anxiety and depression.

What are the Effects of 5-MeO-DMT?

The psychedelic effects of 5-MeO-DMT are believed to primarily arise from its role as a partial agonist at the 5-HT2A receptor, exhibiting a high binding affinity for both the 5-HT2A and 5-HT1A subtypes. However, our understanding of these interactions and their contribution to the psychedelic experience remains limited.

Additionally, 5-MeO-DMT is thought to inhibit the reuptake of neurotransmitters such as serotonin, noradrenaline, and dopamine, although the significance of these mechanisms is not well understood. Therefore, it is strongly advised to avoid combining 5-MeO-DMT with SSRIs, SRIs, MAOIs, RIMAs, or any other substances that act as releasing agents or reuptake inhibitors of monoamine neurotransmitters (such as serotonin and dopamine).

Commonly Reported Effects of 5-MeO-DMT

• Stimulation
• Dissociation
• Suppression and Release of Anxiety
• Feelings of Physical and Cognitive Euphoria
• A Sense of Unity and Interconnectedness
• Catharsis
• Emotion Enhancement
• Ego Death
• Mindfulness
• Rejuvenation
• Autonomous Voice Communication
• Thought Connectivity
• Time Distortion
• Unity and Interconnectedness

Technical Info

Product Name: 5-MeO-DMT Freebase
Other Name(s): 5-methoxy-N,N-dimethyltryptamine
IUPAC Name: 3-[2-(dimethylamino)ethyl]-5-methoxyindole
CAS: 1019-45-0
Formula: C13H18N2O
Molar Mass: 218.3 g/mol

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How to Buy 5-MeO-DMT Freebase online

You can buy 5-MeO-DMT Freebase and other research chemicals here at Chemical Collective. All of our chemicals are third party lab tested. If you wish to see HNMR results for 5-MeO-DMT Freebase or any other chemical, just email us at

Responsible Research with 5-MeO-DMT Freebase

Always practice responsible research. You should read and educate yourself before undertaking research with any chemical. Never conduct research with a chemical without learning about it first.

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5-MeO-DMT Freebase is sale for research purposes only and not for human consumption!

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5-MeO-DMT Freebase last stock update: January 2025